Query profiles let you consistently point your search application at a static endpoint, but give you the flexibility to change the actual query pipeline being used (and optionally, the collection and/or configuration parameters for the query pipeline).
For example, an e-commerce site might want to create a query pipeline to support a month-long promotion. After the query pipeline is configured, it can be easily enabled by changing the query profile in use by the front-end application to use the new pipeline.
To run a query through a query profile, use the REST API as described below. For CRUD operations, you can use either the REST API or the Fusion UI.
Query profiles are configured at Querying > Query Profiles.